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*MTHFR: A GENETIC TEST that may help explain your body’s inability to safely DETOX METALS.

June 3, 2013

Hello Friends,

Most of you know that I have been dealing with copper and heavy metal toxicity for years now.   Recently my current mode of treatment for this, Nutrition Response Testing, has greatly slowed in helping me.  It seems the same patterns and symptoms reappear every month or two.  So I will feel “ok” ( not great, and certainly not energetic) for a few months and then slowly, symptoms like extreme fatigue, weight loss, anxiety, no appetite, heart palps, sleeplessness, diarrhea,  headaches, mood swings, numbness in arms upon napping, and depression , among others return.  Supplements I was taking seem to stop being helpful.  This happens over and over again.  Each time this happens my NRT Practitioner and I will re-address symptoms  and retest all my supplements.  I may start a new supplement only to find in a month or so the same thing happens again.  This has been going on for some time now.  Clearly there is something I am missing.  And I have been feeling like there is an underlying issue that is not being addressed.   While researching mold and other things I discovered a website that got my attention.


This website focuses on the genetic testing for a mutation in the MTHFR gene MTHFR stands for the methylenetetrahydrofolate reductase gene (methyl-ene-tetra-hydro-folate-reductase).   If this gene is mutated then it doesn’t produce the proper enzyme that assists the body in many many processes.   Some of these processes are:

* The turning on and off of genes.

* Gene regulation.

* Processing Folic Acid. (ps: unmetabolized folic acid can cause cancer.)

* Getting rid of environmental toxins.

* Processing hormones.

*Building immune cells.

* Producing ATP= energy.

* Producing nerve coatings.

*and many others.

I am not an expert and certainly have a lot to learn about this subject.  But as I understand it, no matter what you supplement with  or how many detox diets you do, if you have this mutation and do not address it you can  detox all day long and find yourself just  just getting  sicker and sicker.  If you have it,  your body is having trouble metabolizing many things.  Ultimately, all that is not metabolized properly makes the body toxic.  This bit of information seemed to strike a cord with me.   I recently went to my naturopath and had her test me for the mutation.  It should be covered by my insurance as I have some family history of conditions  such as heart disease and schizophrenia that could be caused by MTHFR.  If you have a family history most insurances will cover the testing.  Ask your doctor about the type of history needed.  (I am still waiting on the test results and will keep you posted. )  I have always felt that  even when I was detoxing metals I just couldn’t tolerate the chelating supplements.  I would have to take it and most other supplements in minute doses.  Such extremely small doses that even my practitioner found it to be strange.  I just don’t tolerate them well.  Not tolerating supplements can be a symptom of MTHFR gene mutation.  Of course there are other symptoms and conditions related to MTHFR.   The following are some of these:  (copied from MTHFR.NET )

  1. Autism
  2. Addictions: smoking, drugs, alcohol
  3. Down’s syndrome
  4. Miscarriages
  5. Pulmonary embolisms
  6. Depression in Post-Menopausal Women
  7. Schizophrenia
  8. Fibromyalgia
  9. Chronic Fatigue Syndrome
  10. Chemical Sensitivity
  11. Parkinson’s
  12. Irritable Bowel Syndrome
  13. Pre-eclampsia
  14. Stroke
  15. Spina bifida
  16. Esophageal Squamous cell carcinoma
  17. Acute Lymphoblastic Leukemia
  18. Vascular Dementia
  19. Bipolar disorder
  20. Colorectal Adenoma
  21. Idiopathic male infertility
  22. Blood clots
  23. Rectal cancer
  24. Meningioma
  25. Glioma
  26. Congenital Heart Defects
  27. Infant depression via epigenetic processes caused by maternal depression
  28. Deficits in childhood cognitive development
  29. Gastric Cancer
  30. Migraines with aura
  31. Low HDL
  32. High homocysteine
  33. Post-menopausal breast cancer
  34. Atherosclerosis
  35. Oral Clefts
  36. Type 1 Diabetes
  37. Epilepsy
  38. Primary Closed Angle Glaucoma
  39. Alzheimer’s
  40. Tetralogy of Fallot
  41. Decreased telomere length
  42. Potential drug toxicities: methotrexate, anti-epileptics
  43. Cervical dysplasia
  44. Increased bone fracture risk in post-menopausal women
  45. Multiple Sclerosis
  46. Essential Hypertension
  47. Differentiated Thyroid Carcinoma
  48. Prostate Cancer
  49. Premature Death
  50. Placental Abruption
  51. Myocardial Infarction (Heart Attack)
  52. Methotrexate Toxicity
  53. Nitrous Oxide Toxicity
  54. Heart Murmurs
  55. Tight Anal Sphincters
  56. Tongue Tie
  57. Midline Defects (many are listed above)
  58. Behcet’s Disease
  59. Ischemic Stroke in Children
  60. Unexplained Neurologic Disease
  61. Asthma
  62. Shortness of Breath
  63. Bladder Cancer
  64. Anecephaly

I am  curious to say the least.  I have been struggling with detox issues that stem from metal toxicity for the past four years.   Finding an underlying metabolic problem would really explain a lot.  If  you are struggling with metal detox, hormonal toxicity, among others  you may want to research MTHFR.     It’s  a complex subject but worth a look.


Again the website is:


Wishing you optimal health everyday,


Robin Eckert

Certified Personal Trainer

Licensed Aesthetician

From → Uncategorized

  1. I have an MTHFR variant. I almost died in childbirth.

    MTHFR variants can impair B vitamin status.

    It does not help people with MTHFR variants that the food supply is skewed toward high synthetic folic acid (folic acid is added to all flour products and is in most multivitamins.) Folic acid is not a form of folate that is well-metabolized by everyone.

    High unmetabolized folic acid in the presence of low vitamin B12 appears to be threatening the health of unprecedented numbers of people. Folic acid “masks” a B12 deficiency, allowing it to progress untreated.

    Here is my documentary that gives the history:

  2. I know where you are coming from. I recently found out that I am homozygous 1298 and my husband is hetero 677…. awaiting the kids results. My ND said it could be the cause of my miscarriages, my daughter being born with only half her cerebellum (back of brain) and my son’s severe ADHD. If we had only known! But, spilt milk, so WE KNOW NOW and are supplementing properly and working on other ways to do better. You can check out, and Spectracell’s intracellular micronutrient testing showed just how deficient I was in Vitamin E, selenium and most of all glutathione (NOT a good thing!!) With any luck, I can avoid the cancer I was headed toward without knowing this!!

  3. Terri permalink

    Hi Robin! How did your MTHFR results come back? I have a very similar story to yours as I have seen great docs and been very compliant with diet and supplements, but could never feel better. I thought I was going crazy! After 4.5 years of struggling, I just found out i am compound heterozygous (c677 and a1298). I am awaiting my 23andme results as I couldn’t even tolerate the cream to help methylation which means I probably have snps down the line that I need to deal with first. It is a long, grueling process and I feel lately like I am going to die before I get detoxed and better. It was wonderful reading your story. I hope you are doing well.

    • Hello Terri,

      Thank you so much for writing me. It is always nice to know I am not alone in all this. I did get my results back from mthfr test. I have two mutations, both 1298A. And also did the 23andme which showed other snps as well. I am currently working with a few naturopaths and am considering Shawn Bean for advice as well. I haven’t tried any methylation treatment yet. I wanted to deal with snps first. Unfortunately, the diet is very similar to what I’ve already done. Been there done that. Not too excited about the new info I got from practitioners. Feeling my way through it intuitively. I think my digestion may not be as bad as I think. Yes, it is a grueling process. And after many years already of struggle it is difficult to take on more complicated health stuff. But I am hanging in there! 🙂 I hope you find some relief soon as well. The copper symptoms are truly exhausting. The mthfr stuff is fascinating for sure. And I do enjoy researching it and learning new things. Thank you for reading my story. I really do need to update my blog and you have been a good reminder for me. Feel better soon.

      Wishing you optimal health everyday.

      Robin Eckert
      Certified Personal Trainer
      Licensed Aesthetician

      • maria permalink

        Hi, I am going through a similar health crisis and have tested positive for MTHFR1298C and other SNP’s. I was wondering if you consulted with Shawn Bean. If so, how did it go? I’m considering doing so myself.

      • Hi Maria,

        Yes! I am currently working with Shawn Bean. I haven’t gotten all my labs done yet that he ordered but am working on it. Will let you know how it goes…..


      • maria permalink

        Thanks, for the feedback, I appreciate it. I’ve seen so many integrative and regular Dr’s at this point and am having trouble finding the right expertise getting to the bottom of things. He seems knowledgeable, but I was wondering if he can be helpful sorting things out and getting me on the path to recovery. I’m sure you can relate! Would love to hear any feedback on how he has been of help.

      • maria permalink

        Who do you see for Nutritional Response, would you mind sharing their info? I’m in the Philadelphia area, so not sure if they are local to me.

    • Me and this article, sitting in a tree, L-R–AE-N-I-N-G!

  4. Sheena permalink

    So excited to have found your page!!

    I found in searching for copper toxicity symptoms as I had my IUD for 4 years (just removed recently). In continuing to read, I was also surprised to find info on the MTHFR mutation – I have recently found out that I have a double mutation!
    I would love to talk to you more in depth – any way we could connect on the subjects?
    Thank you for sharing your story.
    All the best,

  5. After reading this I think is quite informative , i appreciate your time and effort to write this posts.

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